Evidence of Positive Selection on a Class I ADH Locus
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چکیده
منابع مشابه
Evidence of positive selection on a class I ADH locus.
The alcohol dehydrogenase (ADH) family of enzymes catalyzes the reversible oxidation of alcohol to acetaldehyde. Seven ADH genes exist in a segment of ~370 kb on 4q21. Products of the three class I ADH genes that share 95% sequence identity are believed to play the major role in the first step of ethanol metabolism. Because the common belief that selection has operated at the ADH1B*47His allele...
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ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 2007
ISSN: 0002-9297
DOI: 10.1086/512485